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Treatment Period: Energy needs for the treatment period (Days 119) were estimated using the following equation, assuming a 20% increased EE on the metabolic ward compared to that in the calorimeters: EI=[EE in calorimeter (average Days -3,-2,-1) 1.2 ] 1000kcal (17)

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For these patients, initiating weight loss injections may be considered if: The potential metabolic benefits (improved diabetes control, cardiovascular risk reduction, weight loss) substantially outweigh gallbladder risks Close monitoring is feasible with regular clinical follow-up Patients understand warning signs of gallbladder complications The rate of weight loss can be moderated through dosing strategies Conversely, patients with symptomatic gallstones experiencing biliary colic (right upper quadrant pain after meals), previous episodes of cholecystitis, or complications such as pancreatitisgenerally should undergo evaluation by a gastroenterologist or surgeon before starting weight loss injections